Found in the connective tissue of the human, the sodium salt of hyaluronic acid has the common name of sodium hyaluronate. It is an extended chain of polymer, glycosaminoglycan and also as disaccharide units of Na-glucuronate-N-acetylglucosamine.Chlamyhyaluronic acid sodium salt is supposed to bind to certain receptors with which it has attraction to, in the matters of chemistry. It’s polyanionic form, the hyaluronate is viscously elastic polymer present in the aqueous and vitreous humor of the ye and in the fluid of articulate joints. It is distributed widely in the extracellular matrix of connective tissues, neural tissues, epithelial tissues and corneal endothelium.
A tissue lubricant
The function of sodium hyaluronate is being the tissue lubricant and it plays vital role in carrying out the communications between tissues which are adjacent to each other. In a solution of water, it becomes viscoelastic. Mechanical security for the tissues of retina, iris and cell layers of cornea, epithelium and endothelium is entertained by the high mushy nature of the liquid. The stretch of solution is assisted in absorbing helps in assisting in the absorbing movement stress and provides a protective air-bag for the tissues. It facilitates the healing if any wound occurs. Just like a transport vehicle it takes the growth factors of peptide and other structures of protein to where the action takes place. Then it degrades as an enzyme and proteins which are active are released so that they can repair the tissue.
After many hours of injecting process, it has residual effect on the cells it touched. The canal of Schlemn eliminates it from the body.
Side effects of Chlamyhyaluronic acid sodium salt
Side effects are rare when Hyaluronic Acid is used in the treatment of joints. In opthalmological procedures, sodium salt of hyaluronate might be the cause of swelling, decompensation of the cornea and temporarily rises in intraocular pressure.
Medical uses as intra-articular treatment when injected
In joint pains of knee like that in the patients of osteoarthritis, who did not receive relief from other way of treatments, Chlamyhyaluronic acid sodium salt is injected in the capsule of the joints so that it can work as a shock absorber for joints. Used in the treatment as a viscous supplement and supported through a series of injections, it spikes the increase of the synovial fluid viscosity so that it lubricates the joint of the knee protecting it from maximum friction. Before any knee surgery, it is injected because it can give symptomatic relief. The process is carried on by recover of the articular fluid and also stimulates the new production of synovial liquid. Use of Sodium hyaluronate reduces the possibility of joint replacement. Once injected, the work starts its effectiveness within four weeks, reaches to it’s maximum strength by eight week and the whole effect lasts till six months or so. It proved to be more efficient than oral analgesics for the treatment of osteoarthritis. It is also effective to treat the ankle joint pains.
When injected to ease the process of ophthalmic surgery
As an aid to the eye surgery, Chlamyhyaluronic acid sodium salt acts as vitreous humor and aqueous. Examples are intra as well as extra capsular extraction of cataract, implantation of intraocular lens, transplant of cornea, filtration of glaucoma, treating dry eyes and the surgery for attaching retina. For surgeries, especially for the anterior part of the eyeball, the installing of Chlamyhyaluronic acid sodium salt solution increases the viscoelasticity and enhances the maintaining of a deep area during the surgical process. The fluid makes sure that it does not flow out during the surgical procedure. It’s also less traumatic to the corneal endothelium and other surrounding tissues. The viscoelasticity helps to push the face of vitreous back and also stops from the formation of any flat chamber. For the surgery of posterior part, Chlamyhyaluronic acid sodium salt solution acts as a surgical assistant to gently separate and hold the tissues. It also make a clear vision, enhances inspection of photocoagulation and retina during and after the surgical procedure.
As the topical medication for ailments
When applied from the dermal platform, the sodium hyaluronate gets absorbed as biomacromolecules and work just like nanocarriers.